KMID : 0614620020400060355
|
|
Korean Journal of Gastroenterology 2002 Volume.40 No. 6 p.355 ~ p.363
|
|
Expression of Integrin ¥á5, ¥á6, ¥áV, ¥â1, ¥â2, ¥â3, ¥â4 Subunits in Gastric Cancer
|
|
Gham Chang-Woo
Park Seung-Woo Shin Yule Kim Hyun-Wook Kim Han-Soo Song Si-Young Chung Jae-Bock Kang Jin-Kyung Noh Sung-Hoon
|
|
Abstract
|
|
|
Background/Aims: The intergrins play a central role in maintaining the morphology of cell and tissue, growth, differentiation, migration, survival and apoptosis of cells, and angiogenesis. Although integrins are implicated in carcinogenesis and tumor angiogenesis, their precise contributions to the process are largely unknown.
Methods: For paraffin embedded tissue samples of 102 gastric cancers (23 differentiated, 79 undifferentiated), the expression of integrin ¥á5,¥á6, ¥áV, ¥â1, ¥â2, ¥â3, ¥â4 subunits and factor ¥· were examined by immunohistochemical staining.
The relationships between the expression of each integrin and several clinicopathologic parameters were analyzed.
Results: The positive rates of integrins were as follows: ¥á5 24%, ¥â1 8%, ¥á6 16%, ¥â4 24%, ¥áV 29%, and ¥â3 34%. The expression of ¥á5, ¥á6, and ¥áV was well correlated with the the expression of ¥â1, ¥â4 and ¥â3, respectively. The ¥áV
integrin was highly expressed in tumors of advanced T stage. The expression of ¥á6 and ¥â4 integrins were significantly higher in differentiated tumors, but the ¥â3 integrin was significantly expressed in undifferentiated tumors. The number of tumor vessels has positive correlation with ¥áV integrin expression.
Conclusions: These findings suggest that integin ¥á6, ¥â4 is one of the key factors in determining tumor differentiation and growth pattern. The integrin ¥áV ¥â3 may be related to hte angiogenesis especially in advanced gastric cancer.
|
|
KEYWORD
|
|
Stomach neoplasms, Intergin, Immunohistochemical stain
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|